An aggressive attack on the fire in a building on Route 125 helped bring it under control within 10 minutes, and contained the damage to one apartment.
Matthew Wilson suffered serious injuries in his lower extremities in the crash early Friday morning and was flown by medical helicopter to Tufts Medical Center.
The Plaistow Fire Department said the fire was its fourth fire of the week including the nine alarm fire at Michael's Oceanfront Motel in Salisbury early Monday morning.
The Essex County District Attorney's Office told Seacoast Current that a death connected to the crash is under investigation but did not disclose details.